As a folded membrane in charge of synthesis and transportation of proteins and lipids in the cell, the endoplasmic reticulum may seem like the obvious choice for the job of chief organelle. You may not know however, that its dysfunction is linked to a multitude of neurological diseases such as cerebral ischemia, sleep apnea, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, prion diseases and familial encephalopathy. With so many opportunities for malfunction, how could you confidently vote for the endoplasmic reticulum?
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Roussel, B D, et al. “Endoplasmic Reticulum Dysfunction in Neurological Disease.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Jan. 2013, www.ncbi.nlm.nih.gov/pubmed/23237905.
Roussel, B D, et al. “Endoplasmic Reticulum Dysfunction in Neurological Disease.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Jan. 2013, www.ncbi.nlm.nih.gov/pubmed/23237905.
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